（一）个人简介
刘执坤 男，1990年10月生， 博士， 2021年于东南大学获得博士学位，2021年8月就职于淮阴工学院江苏省特色资源开发与药用研究重点实验。主要从事药物化学，化学生物学等研究工作，基于生物信息和话化学信息药物设计研究、开展创新型药物设计。近年来发表国际知名学术杂志，如Journal of Medicinal Chemistry，European Journal of Medicinal Chemistry、Bioconjugate Chemistry、Bioorganic Chemistry、 Bioorganic & Medicinal Chemistry 15余篇。参与多项国家自然科学基的研究。
(二) 研究领域与方向
Ø 针对肿瘤的发生、发展及转移相关机制，设计、开发功能型抗肿瘤化合物
Ø 基于微环境在阿尔茨海默病中的作用，设计、开发微环境响应型抗阿尔茨海默病化合物。
（三）代表论文
1. Zhikun Liu, Meng Wang1, Hengshan Wang, Lei Fang*, and Shaohua Gou*， Platinum-based modification of styrylbenzylsulfones as multifunctional antitumor agents: targeting the RAS/RAF pathway, enhancing antitumor activity, and overcoming multidrug Resistance, Journal of Medicinal Chemistry. 2020, 63, 186-204.
2. Zhikun Liu, Meng Wang1, Hengshan Wang, Lei Fang*, Shaohua Gou*, Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance, European Journal of Medicinal Chemistry. 2020, 194, 11296.
3. ZhikunLiu, BinZhang1, ShengjinXia, LeiFang*， ShaohuaGou*, ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker, European Journal of Medicinal Chemistry. 2021, 212, 112997.
4. ZhikunLiu, LeiFang, HuanZhang, ShaohuaGou, LiChen*, Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property, Bioorganic & Medicinal Chemistry. 2017, 2387–2398.
5. Zhikun Liu, Qingqing Liu, Bin Zhang, Qiao Liu, Lei Fang, Shaohua Gou. Blood−brain barrier permeable and NO-releasing multifunctional nanoparticles for Alzheimer’s disease treatment: Targeting NO/cGMP/CREB signaling pathways. Journal of Medicinal Chemistry, 2021, 64(18): 13853–13872.
6. Qingqing Liu, Zhikun Liu, Wuyang Hua, and Shaohua Gou*, Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol derivatives as glutathione transferase inhibitors with favorable selectivity and tolerated toxicity, Journal of Medicinal Chemistry. 2021, 64, 3, 1701–1712.
7. Bin, Zhang, ZhikunLiu, ShengjinXia, QingqingLiu, ShaohuaGou*, Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors, European Journal of Medicinal Chemistry. 2021, 216，113300
8. MengWang, ZhikunLiu, XiaochaoHuang*, YuanhangChen, YanmingWang, JingKong, YongYang, ChunhaoYu, JinLi, XuWang, HengshanWang*, Dual-target platinum(IV) complexes exhibit antiproliferative activity through DNA damage and induce ER-stress-mediated apoptosis in A549 cells, Bioorganic Chemistry. 2021,110, 104741.
9. XiaochaoHuang, ZhikunLiu, MengWang, XiulianYin, YanmingWang, LumeiDai, HengshanWang*, Platinum(IV) complexes conjugated with chalcone analogs as dual targeting anticancer agents: In vitro and in vivo studies, Bioorganic Chemistry. 2020,105,104430.
10. Dihai Gu, Zhikun Liu, HongshuaiWu, Peijing An, Xu Zhi, YujieYin, Wen Liu, BaiwangSun. Dual catalytic cascaded nanoplatform for photo/chemodynamic/ starvation synergistic therapy, Colloids and Surfaces B: Biointerfaces. 2021, 199, 111538.
11. Xiaochao Huang, Shixian Hua, Rizhen Huang, Zhikun Liu, Shaohua Gou*, Zhimei Wang, Zhixin Liao and Hengshan Wang *, Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues. European Journal of Medicinal Chemistry. 2018, 148, 1-25.
