（一）个人简介

喻春皓，博士，博士后，教授，英国帝国理工学院、美国芝加哥大学访问学者。现就职于淮阴工学院化学工程学院制药工程系，江苏省特色资源开发与药用研究重点实验室，2017.03至2022.03期间任制药工程系主任、制药工程专业负责人，期间主持申报并获批江苏省品牌专业—制药工程专业。先后在英国帝国理工学院医学部糖科学实验室、美国芝加哥大学医学院唐仲英植物药研究中心访问交流。博士后工作完成于天津大学化学工程与技术博士后流动站及天津天士力集团有限公司博士后工作站，博士与硕士均毕业于天津大学化工学院、天津大学化学工程研究所，本科毕业于西华师范大学（原“四川师范学院”）。主持及参与6项省级以上科研项目，4项市厅级科研项目；已在Clinical & Translational Oncology、Cancer Prevention Research、Journal of Ginseng Research、Journal of Proteome Research、Journal of Pharmaceutical and Biomedical Analysis、Phytotherapy Research、Pharmaceutical Biology、Oncology Reports、药学学报、中成药等国内外知名学术期刊上发表科研论文30多篇，其中SCI收录论文20篇以上；申请发明专利10余件，授权专利5件；获淮安市科学技术进步二等奖1项，淮安市优秀自然科学论文一等奖1项，江苏省教学成果一等奖1项。

（二）研究领域与招生方向

1）研究领域与方向

Ø 本草源纳米材料加工及应用

Ø 制药-生物工程与大健康产品研发

Ø 天然药物の生物炼制

Ø 中药の生物加工

2）招生方向

Ø 应用化学（制药工程方向）

Ø 生物化工（生物制药方向）

（三）取得成果

1）科研论文

[1] Wang CZ, Zhang CF, Luo Y, Yao H, Yu C (Yu Chunhao), Chen L, Yuan J, Huang WH, Wan JY, Zeng J, Sawadogo WR, Yuan CS, Baicalein, an enteric microbial metabolite, suppresses gut inflammation and cancer progression in ApcMin/+ mice, Clin Transl Oncol, 2020, 22(7): 1013-1022 (IF3.405)

[2] Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C (Yu Chunhao), Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS, Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected], Clin Transl Oncol, 2018, 20(3): 302-312 (IF3.405)

[3] Ma WK, Li H, Dong CL, He X, Guo CR, Zhang CF, Yu CH (Yu Chun-Hao), Wang CZ, Yuan CS, Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines, Mol Med Rep, 2016, 14(1): 491-498 (IF2.952)

[4] Du WJ, Yang XL, Song ZJ, Wang JY, Zhang WJ, He X, Zhang RQ, Zhang CF, Li F, Yu CH (Yu Chun-Hao), Wang CZ, Yuan CS, Antitumor Activity of Total Flavonoids from Daphne genkwa in Colorectal Cancer, Phytother Res, 2016, 30(2): 323-330 (IF5.878)

[5] Wang CZ, Yu C (Yu Chunhao), Wen XD, Chen L, Zhang CF, Calway T, Qiu Y, Wang Y, Zhang Z, Anderson S, Wang Y, Jia W, Yuan CS, American Ginseng Attenuates Colitis-Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics, Cancer Prev Res (Phila), 2016, 9(10): 803-811 (IF3.491)

[6] Wang CZ, Zhang Z, Wan JY, Zhang CF, Anderson S, He X, Yu C (Yu Chunhao), He TC, Qi LW, Yuan CS, Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer, Nutrients, 2015, 7(2): 799-814 (IF5.717)

[7] Xie G, Wang CZ, Yu C (Yu Chunhao), Qiu Y, Wen XD, Zhang CF, Yuan CS, Jia W, Metabonomic Profiling Reveals Cancer Chemopreventive Effects of American Ginseng on Colon Carcinogenesis in Apc(Min/+) Mice, J Proteome Res, 2015, 14(8): 3336-3347 (IF4.466)

[8] Yu C (Yu Chunhao), Wen XD, Zhang Z, Zhang CF, Wu X, He X, Liao Y, Wu N, Wang CZ, Du W, He TC, Yuan CS, American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice, J Ginseng Res, 2015, 39(3): 230-237 (IF6.06)

[9] Yu C (Yu Chunhao), Wen XD, Zhang Z, Zhang CF, Wu XH, Martin A, Du W, He TC, Wang CZ, Yuan CS, American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice, J Ginseng Res, 2015, 39(1): 14-21 (IF6.06)

[10] Wen XD, Wang CZ, Yu C (Yu Chunhao), Zhao L, Zhang Z, Matin A, Wang Y, Li P, Xiao SY, Du W, He TC, Yuan CS, Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model, Phytother Res, 2014, 28(6): 892-898 (IF5.878)

[11] Lian F, Li G, Chen X, Wang X, Piao C, Wang J, Hong Y, Ba Z, Wu S, Zhou X, Lang J, Liu Y, Zhang R, Hao J, Zhu Z, Li H, Fang Liu H, Cao A, Yan Z, An Y, Bai Y, Wang Q, Zhen Z, Yu C (Yu Chunhao), Wang CZ, Yuan CS, Tong X, Chinese herbal medicine Tianqi reduces progression from impaired glucose tolerance to diabetes: a double-blind, randomized, placebo-controlled, multicenter trial, J Clin Endocrinol Metab, 2014, 99(2): 648-655 (IF5.958)

[12] Zhang Z, Yu C (Yu Chunhao), Zhang CF, Wu XH, Wen XD, Anderson S, Du W, Huang WH, Li SP, Wang CZ, Yuan CS, Chemopreventive effects of oplopantriol A, a novel compound isolated from Oplopanax horridus, on colorectal cancer, Nutrients, 2014, 6(7): 2668-2680  (IF5.717)

[13] Zhang CF, Zhang SL, He X, Yang XL, Wu HT, Lin BQ, Jiang CP, Wang J, Yu CH (Yu Chun-Hao), Yang ZL, Wang CZ, Li P, Yuan CS, Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats, J Ethnopharmacol, 2014, 153(3): 793-800  (IF4.36)

[14] Yu C (Yu Chunhao), Wang CZ, Zhou CJ, Wang B, Han L, Zhang CF, Wu XH, Yuan CS, Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis, J Pharm Biomed Anal, 2014, 99: 8-15  (IF3.935)

[15] Wen XD, Wang CZ, Yu C (Yu Chunhao), Zhang Z, Calway T, Wang Y, Li P, Yuan CS, Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis, Am J Chin Med, 2013, 41(5): 1097-1108  (IF4.667)

[16] Yu C (Yu Chunhao), Zhang Z, Zhang H, Zhen Z, Calway T, Wang Y, Yuan CS, Wang CZ, Pretreatment of baicalin and wogonoside with glycoside hydrolase: a promising approach to enhance anticancer potential, Oncol Rep, 2013, 30(5): 2411-2418  (IF3.906)

[17] Wang CZ, Li B, Wen XD, Zhang Z, Yu C (Yu Chunhao), Calway TD, He TC, Du W, Yuan CS, Paraptosis and NF-κB activation are associated with protopanaxadiol-induced cancer chemoprevention, BMC Complement Altern Med, 2013, 13: 2  (IF3.659)

[18] Wang CZ, Zhang Z, Huang WH, Du GJ, Wen XD, Calway T, Yu C (Yu Chunhao), Nass R, Zhao J, Du W, Li SP, Yuan CS, Identification of potential anticancer compounds from Oplopanax horridus, Phytomedicine, 2013, 20(11): 999-1006  (IF5.34)

[19] Wang CZ, Calway TD, Wen XD, Smith J, Yu C (Yu Chunhao), Wang Y, Mehendale SR, Yuan CS, Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway, Int J Oncol, 2013, 42(3): 1018-1026 (IF5.65)

[20] Yu C (Yu Chunhao), Qu F, Mao Y, Li D, Zhen Z, Nass R, Calway T, Wang Y, Yuan CS, Wang CZ, Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis, Pharm Biol, 2013, 51(10): 1228-1235  (IF3.503)

[21] Du GJ, Zhang Z, Wen XD, Yu C (Yu Chunhao), Calway T, Yuan CS, Wang CZ, Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea, Nutrients, 2012, 4(11): 1679-1691  (IF5.717)

[22] Huang X, Wang M, You Q, Kong J, Zhang H, Yu C (Yu Chunhao), Wang Y, Wang H, Huang R, Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents, Eur J Med Chem, 2020, 189: 112067  (IF6.514)

[23] Huang X, Wang M, Wang C, Hu W, You Q, Ma T, Jia Q, Yu C (Yu Chunhao), Liao Z, Wang H, Synthesis and biological evaluation of novel millepachine derivative containing aminophosphonate ester species as novel anti-tubulin agents, Bioorg Chem, 2020, 94: 103486  (IF5.275)

[24] Huang X, Wang M, Wang C, Hu W, You Q, Yang Y, Yu C (Yu Chunhao), Liao Z, Gou S, Wang H, Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance, Bioorg Chem, 2019, 92: 103236 (IF5.275)

[25] Wang YM, Yu CH (Yu Chun-Hao), Zhao XJ, Zhao JQ, A rapid high-performance liquid chromatography separation of a new anthocyanin from Nitraria tangutorum, J Asian Nat Prod Res, 2020, 22(5): 503-507  (IF1.569)

[26] Shi Y, Xiong Q, Wang X, Li X, Yu C (Yu Chunhao), Wu J, Yi J, Zhao X, Xu Y, Cui H, Characterization of a novel purified polysaccharide from the flesh of Cipangopaludina chinensis, Carbohydr Polym, 2016, 136: 875-883  (IF9.381)

[27] Gao W, Su X, Dong X, Chen Y, Zhou C, Xin P, Yu C (Yu Chunhao), Wei T, Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells, Oncol Rep, 2015, 33(3): 1107-1114  (IF3.906)

[28] 王绒, 杨勇, 施晓琪, 邹雯燕, 付晨伟, 纪香峰, 喻春皓, 崔超, 孔晶, HPLC法同时测定蒿茶中3种有机酸的含量, 淮阴工学院学报, 2020, 29(03): 61-65

[29] 杨勇, 喻春皓, 王绒, 施晓琪, 地方工科高校制药工程专业文献检索教学改革初探, 广东化工, 2018, 45(14): 241-242

[30] 王斌, 魏连刚, 徐大超, 赵恩春, 喻春皓, 基于PCR-DGGE方法探讨益脾止泻汤对溃疡性结肠炎患者的微生态调节, 中医药学报, 2016, 44(05): 24-27

[31] 喻春皓, 《制药分离工程》的项目课程教学法探析, 广东化工, 2015, 42(15): 264-265

[32] 喻春皓, 王冲之, 袁钧苏, 西洋参抗癌研究进展——以结直肠癌为研究范例, 药学学报, 2013, 48(07): 986-992

[33] 喻春皓, 吴洁, 酶法加工对生晒参中皂苷部位的影响及高效液相色谱分析, 时珍国医国药, 2013, 24(03): 656-658

[34] 喻春皓, 吴洁, 生晒参乙醇提取物直接酶法转化及液质分析, 中成药, 2012, 34(09): 1747-1752

[35] 喻春皓, 张萍, 王宏志, 正交试验优选蒸制黄芩的纤维素酶辅助提取工艺, 中国药房, 2009, 20(36): 2826-2827

[36] 喻春皓, 制药工程专业中药化学的教学方法探析, 亚太传统医药, 2009, 5(12): 160-163

[37] 喻春皓, 张萍, 王宏志, 纤维素酶辅助提取生黄芩饮片中黄酮苷元的工艺研究, 安徽农业科学, 2009, 37(35): 17692-17694+17697

[38] 喻春皓, 张萍, 师静静, 响应曲面法优化银杏叶萜内酯的纤维素酶辅助提取工艺, 亚太传统医药, 2009, 5(11): 20-23

[39] 喻春皓, 张海江, 张萍, 中草药生物转化工程与中医药创新, 亚太传统医药, 2009, 5(06): 1-4

[40] 王宏志, 喻春皓, 高钧, 赵广荣, HPLC分析比较炮制和提取方法对黄芩活性成分的影响, 中国中药杂志, 2007, 32(16): 1637-1640

[41] 王宏志, 喻春皓, 高钧, 赵广荣, 酶法提取黄芩中黄芩素、汉黄芩素, 中药材, 2007, 30(07): 851-854

[42] 李兵, 喻春皓, 魏峰, 高瑞昶, 元英进, 复合式酶法提取丹酚酸B, 化学工业与工程, 2007, 24(02): 187-189

[43] 喻春皓, 魏峰, 何志敏, 酶法修饰人参茎叶总皂苷及其HPLC图谱研究, 中草药, 2007, 38(01): 46-50

[44] 杨立志, 喻春皓, 何志敏, 功能性低聚糖功效及生产概况, 天津化工, 2001, (01): 13-15

[45] Yu C, Wang Y, Zou W, Wang R, Yang Y. Research on data mining and visual technology application in the process of traditional Chinese Medicine pharmacy. Boletín Técnico, 2017, 55(18): 345-351 (EI收录)

[46] Yu, Chunhao; Wu, Jie; Zhang, Haijiang; Wang, Hongzhi. Comparison of the major flavonoid content of raw and steamed Scutellariae Radix by high-performance liquid chromatography. 2012 International Conference on Biomedical Engineering and Biotechnology (EI收录)

[47] 陈汝珺, 王亚茹, 付晨伟, 陈瑾, 陆正清, 喻春皓. 凹凸棒石的氨基硅烷化及人参提取物中农残吸附. 淮阴工学院学报, 2020, 29(5): 42-48

[48] Meng Wamg, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yangmin Wang, Jing Kong, Yong Yang, Chunhao Yu, Xu Wang, Hengshan Wang. Dual-target platinum(IV) complexes exhibit antiproliferative activity through DNA damage and induce ER-stress-mediated apoptosis in A549 cells. Bioorganic Chemistry, 2021, 110: 104741  (IF5.275)

注：以上影响因子（IF）与分区为2020年发布的影响因子与分区。

2）代表专著与专利

[1] 喻春皓, 王亚茹, 邹雯燕, 夏尧干, 冒顾政, 宋悉玲, 周跃, 刘雨婷, 胡天乐, 焦晓薇, 刘彤. 一种硅烷改性凹土的制备方法及其在中草药农残脱除中的应用, 2021.05.25, 中国, ZL 201811068878.3

[2] 吴洁, 喻春皓, 熊清平, 李东. 制药工程基础与专业实验. 南京: 南京大学出版社, 2014

[3] 喻春皓, 张萍, 吴洁. 基于生物催化法制备的“去火”人参, 2011.04.09, 中国, ZL201110088181.4

3）科研项目及教学教改项目

[1] 2021.12主持及获批江苏省品牌专业，制药工程，在研

[2] 2020.12主持获批江苏省高等学校重点教材一门，《工业药剂学》，主持在研

[3] 江苏省高等学校自然科学研究重大项目，18KJA360001，内源苷酶介导半夏泻心汤加工过程显效物质形成机制研究，主持结题, 15万

[4] 江苏省科技厅产学研前瞻性联合研究项目，BY2016061-22，人参属药材及其提取物中农药残留脱除关键技术研究，2016.7~2018.12，主持结题， 30万

[5] 淮安市兄弟生物科技有限公司-横向科研课题，人参属药材提取物农药残留脱除关键技术研究，2016.1~2018.12，主持结题, 60万

[6] 江苏省自然科学基金项目，BK2008194，复合酶法转化人参属药材中天然皂苷部位的机理研究，2008.09~2011.12，主持结题, 8万, 学校配套12万

[7] 淮安市应用研究与科技攻关（工业）计划，HAG2014036，微生物酶法高效制备黄芩素和汉黄芩素的工艺研究，2014.09~ 2016.12，主持结题, 6万

[8] 国家自然科学基金委员会,青年基金项目，51503073，聚烯烃表面微观结构构建及其与血小板作用机制研究，2016.01-2019.12，参与结题（排名第二），20万

[9] 江苏省中医药局，科技项目，LZ11163，基于PCR-DGGE方法探讨益脾止泻汤对溃疡性结肠炎患者的微生态调节，2012-01至2014-12，2万，共同主持结题(排名第二), 2万

江苏省科技厅工业支撑项目，BE2009098，新型药物缓释用聚合物/凹凸棒黏土复合纳米材料的研发，2009.04~2011.12，参与结题(排名第二), 40万